盐诱导激酶2的研究进展

Advances of The Study on Salt-Inducible Kinase 2

盐诱导激酶(salt-inducible kinase,SIK)是属于单磷酸腺苷激活蛋白激酶/蔗糖非酵解1(adenosine monophosphate-activated protein kinase and sucrose non-fermenting 1,AMPK/SNF1)家族的丝氨酸/苏氨酸蛋白激酶。SIK自1998年被发现以来,越来越多的功能被人们证实和认可。现已发现,SIK在能量代谢、细胞信号转导、细胞周期、肿瘤、黑素原生成等诸多方面有重要作用。通过查阅近些年相关文献,在此重点总结一下SIK2功能的研究进展。

Salt-inducible kinase is a serine/threonine kinase, belonging to adenosine monophosphate-activated protein kinase and sucrose non-fermenting 1 （AMPK/SNF1） family. More and more functions have been confirmed and approved since SIK was found in 1998. SIKs were found to play key roles in energy metabolism, signal transduction, cell cycle, tumor, melanogenesis and so on. By reviewing the relevant researches in recent years, the authors focused on the functions of SIK2 in this review.