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DNA损伤修复蛋白XRCC1的研究进展 被引量：5

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摘要 X线修复交叉互补蛋白1(XRCC1)在碱基切除修复(BER)以及单链断裂损伤修复(SSBR)中起着支架蛋白的作用。XRCC1可以与多个DNA修复相关蛋白交互作用并招募到DNA损伤部位,最终完成DNA的修复。由于XRCC1在DNA修复通路的重要作用,主要突变体Arg194Trp、Arg280His以及Arg399Gln也被深入地研究。在本文中作者对XRCC1的结构、功能以及它的突变体在人类疾病发生中的作用作一概述。
作者 徐诚 严丽锋 王心如 顾爱华
机构地区 南京医科大学公共卫生学院
出处 《东南大学学报（医学版）》 CAS 2014年第3期376-380,共5页 Journal of Southeast University(Medical Science Edition)
关键词 X线修复交叉互补蛋白1 DNA修复 突变体 文献综述
分类号 Q754 [生物学—分子生物学]
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参考文献48

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二级参考文献8

共引文献3

同被引文献59

  • 1王亚林,江军.谷胱甘肽巯基转移酶基因多态性与前列腺癌风险相关性[J].临床泌尿外科杂志,2005,20(2):123-126. 被引量：5
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引证文献5

二级引证文献2

东南大学学报（医学版）
2014年 第3期

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