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PI3K/Akt信号通路在肿瘤研究中的进展 被引量：31

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摘要 磷酯酰肌醇-3激酶/蛋白激酶B(PI3K/Akt)信号通路是肿瘤、炎症等发生发展过程中一条重要的信号通路。研究发现,在许多肿瘤组织中,PI3K/Akt信号通路过度表达和活化与肿瘤的进展密切相关。上游分子通过与PI3K结合,使其构象发生改变,从而磷酸化激活Akt,Akt的活化能调控其下游分子,参与肿瘤调控通路。近年来,PI3K/Akt信号通路在肿瘤中的重要作用受到众多学者的关注,多种肿瘤组织中检测到PI3K/Akt信号通路的过度活化,因此靶向该信号通路的研究成为研究热点。目前关于靶向PI3K/Akt信号通路的抗肿瘤药物在肿瘤治疗方面的临床试验已经展开,Wortmannin、LY294002等PI3K/Akt信号通路抑制剂有着广阔的临床应用前景。
作者 李建 周怀君
机构地区 东南大学医学院 南京大学附属鼓楼医院妇产科
出处 《东南大学学报（医学版）》 CAS 2014年第3期392-395,共4页 Journal of Southeast University(Medical Science Edition)
关键词 磷酯酰肌醇-3激酶 蛋白激酶B 肿瘤 文献综述
分类号 R730.231 [医药卫生—肿瘤]
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参考文献32

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二级参考文献44

  • 1石松长,黄昌明.PI_3K[MS1]/Akt信号通路与消化道肿瘤的研究进展[J].医学综述,2007,13(14):1070-1072. 被引量：5
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共引文献13

同被引文献438

引证文献31

二级引证文献210

东南大学学报（医学版）
2014年 第3期

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