瞬时波强技术对不同血糖水平者颈动脉弹性的临床研究

Clinical study of carotid elasticity in subjects with different plasma glucose level by wave intensity

目的 探讨瞬时波强（WI）技术评价不同血糖水平者颈动脉弹性的临床价值.方法 研究对象按照血糖水平分为三组：A组（正常血糖对照组）,B组（正常血糖偏高组）,C组（糖尿病前期组）.应用WI技术测量颈动脉负向波面积（NA）、收缩晚期波（W2）、僵硬度（β）、压力应变弹性系数（Ep）、增大系数（AI）、顺应性（AC）及脉搏波传导速度（PWVβ）.结果 WI参数中,与A组比较,C组的W2、β、Ep、PWVβ均明显增高,AC减低,差异有统计学意义（P＜0.05）,NA在两组间差异无统计学意义;B组中所有指标与A组比较差异均无统计学意义（P＞0.05）.结论 WI技术能评价颈动脉弹性改变,糖尿病前期组颈动脉已发生弹性降低,正常血糖偏高组未发现明显颈动脉弹性改变.

Objective To assess the carotid elasticity using wave intensity（WI） in subjects with different plasma glucose level.Methods 107 subjects were enrolled in this study,according to their plasma glucose levels,subjects were categorized as normal plasma glucose group （group A）,normal plasma glucose in higher level group （group B） and pre-diabetes group （group C）.Carotid WI examination was performed and analyzed.The parameters included magnitude of the peak during late systole （W2）,negative area during the mid-ejection （NA）,and stiffness parameter （β）,pressure strain elasticity modulus （Ep）,arterial compliance（AC）,augmentation index（AI）,one point pulse wave velocity（PWVβ）.Results Compared to group A,W2,β,Ep,PWVβ increased significantly while AC decreased in group C（P 〈0.05）,but there was no obvious difference of NA between two groups.Furthermore,this statistically difference was not found in group B（P 〉0.05）.Conclusions Carotid elasticity have been altered in pre-diabetes group which can be evaluated by WI,but no marked change is observed in normal plasma glucose of higher level group.