舌下粉尘螨滴剂加用氟替卡松治疗变应性鼻炎的疗效观察

Clinical efficacy of Dermatophagoides Farina Drops combined with fluticasone in treating allergic rhinitis

目的：探讨舌下含服特异性免疫治疗（Sublingual Immunotherapy，SLIT）配合氟替卡松治疗变应性鼻炎的有效性和安全性。方法采用患者治疗前后自身对照方法，比较39例7～60岁的变应性鼻炎患者在治疗前及免疫治疗1年、2年后的症状评分、药物评分以及不良反应发生率，评价其疗效和安全性。以SPSS17.0软件对数据进行统计学分析。结果治疗前变应性鼻炎患者的症状评分及药物评分分别为（3.22±0.66）、（3.09±1.01）分，治疗后1年分别为（1.68±0.61）、（1.89±0.64）分，治疗后2年分别为（0.61±0.22）、（1.49±0.38）分。结果表明通过免疫治疗，变应性鼻炎患者的症状和用药情况均显著改善（P值均＜0.01），且治疗时间越长，疗效越显著。治疗过程中未发生严重不良事件，部分患者表现为口腔不适感。结论舌下含服标准化粉尘螨变应原疫苗加用氟替卡松是一种治疗尘螨过敏变应性鼻炎的安全有效方法。

Objective To evaluate the efficacy and safety of sublingual immunotherapy with Dermatophagoides Farinae Drops in combination with fluticasone in treating allergic rhinitis.Methods 39 patients with allergic rhinitis aged from 7 to 60 years were enrolled in and treated with Dermatophagoides farinae Drops and fluticasone in this research. Before and after one or two years of treatment, Rhinitis symptoms scores, medication scores and incidence of adverse reactions were evaluated and analyzed by SPSS17.0 software.Results After one year of treatment, the symptoms and medication scores were dramatically decreased from 3.22±0.66 and 3.09±1.01 to 1.68±0.61 and 1.89±0.64 （P〈0.01） respectively. After two years of treatment, they decreased to 0.61±0.22 and 1.49±0.38 （P〈0.01）. No severe adverse events was observed, except oral cavity discomfort in several patients.Conclusion Combination therapy of Dermatophagoides farinae Drops and fluticasone is safe and effective for allergic rhinitis.