摘要
Plasmacytoid dendritic cells （pDCs） express intracellular Toll-like recep-tors （TLRs） 7 and 9 and, once activated, produce large amounts of （anti-viral） type I interferons. As such, pDCs play a key role in the physiopathology of the immune response and in infection, auto- immunity and tumors. In the current issue of Nature Immunology, Agudo and colleagues report that the survival and function of pDCs are modulated by the microRNA miR-126 via the VEGFR2 pathway. These findings unveil the unknown capacity of miR-126--a microRNA that had previously been associated only with angiogenesis--to control pDCs homeostasis,
Plasmacytoid dendritic cells （pDCs） express intracellular Toll-like recep-tors （TLRs） 7 and 9 and, once activated, produce large amounts of （anti-viral） type I interferons. As such, pDCs play a key role in the physiopathology of the immune response and in infection, auto- immunity and tumors. In the current issue of Nature Immunology, Agudo and colleagues report that the survival and function of pDCs are modulated by the microRNA miR-126 via the VEGFR2 pathway. These findings unveil the unknown capacity of miR-126--a microRNA that had previously been associated only with angiogenesis--to control pDCs homeostasis,
