口腔鳞癌转移与特异性核基质结合区结合蛋白质1(SATB1)表达的关系

Relationship between Expression of Special AT-rich Sequence Binding protein1(SATB1)and Progression,Metastasis in Oral Squamous Cell Carcinoma

目的：检测特异性核基质结合区结合蛋白质1在口腔鳞状细胞癌中的表达及其与浸润转移的关系。方法：采用免疫组织化学染色法及逆转录-聚合酶链反应检测SATB1在各组织中的表达。结果：52例口腔鳞癌原发灶中,SATB1蛋白在病理分级Ⅱ~Ⅲ级组（中~低分化鳞癌）表达明显高于Ⅰ级组（高分化鳞癌）（P〈0.05）;在临床分期Ⅲ~Ⅳ期组高于Ⅰ~Ⅱ期组（P〈0.05）。SATB1蛋白和mRNA的表达在16例淋巴结转移组高于36例无淋巴结转移组（P〈0.05）。SATB1mRNA的表达量在6例淋巴结转移灶高于16例转移组原发灶（P〈0.05）。结论：SATB1蛋白及SATB1mRNA在口腔鳞癌中的表达上调与口腔鳞癌的恶性程度及转移相关;SATB1可能在口腔鳞癌的发展、转移过程中起到促进的作用。

Objective：To detect the correlation between expression of special AT-rich sequence binding protein 1（SATB1）and progression,metastasis of oral squamous cell carcinoma（OSCC）.Methods：The SATB1expression levels were detected by immunohistochemical staining and transcription-polymerase chain reaction（RT-PCR）.Results：The expression of SATB1protein in primary tumor tissue in histology gradeⅡ~Ⅲ OSCC was obviously higher than that in histology gradeⅠ,and in clinical stageⅢ-Ⅳ OSCC than that in histology gradeⅠ-Ⅱ,respectively.On the other hand,the expression of SATB1protein and mRNA of primary tumor tissue in 16cases of metastasis of lymph node group was significantly higher than 36cases of non-metastasis group.The expression of SATB1mRNA in 6metastatic tissue in lymph nodes was higher than in 16cases of primary lesions in tumor.Conclution：The upregulation of SATB1protein and mRNA may be related with the classification and metastasis of OSCC, and play apromoting role in the progression and metastasis of OSCC.