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听觉受损后听觉中枢GABA通路的物质改变 被引量：8

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摘要 噪声、机械损伤以及老龄化等因素造成听力损伤后会引起中枢听觉系统的一系列改变，导致听觉功能重塑，最常见的是听力损伤后耳鸣现象。γ-氨基丁酸（gamma-aminobutyric acid ，GABA）是中枢神经系统中重要的抑制性神经递质，听觉损伤后GABA通路物质的变化可能参与中枢听觉通路的去抑制作用。本文旨在总结近年来听觉损伤后中枢GABA通路各物质的变化，为研究听觉功能重塑机制提供参考。
作者 李孛 冯艳梅 殷善开
机构地区 上海市第六人民医院耳鼻咽喉科
出处 《听力学及言语疾病杂志》 CAS CSCD 北大核心 2014年第3期317-320,共4页 Journal of Audiology and Speech Pathology
基金 国家杰出青年基金(30925035) 国家自然科学基金面上项目(81070778)联合资助
关键词 听觉中枢 GABA 听觉通路 物质 抑制性神经递质 中枢听觉系统 Γ-氨基丁酸 中枢神经系统
分类号 R339.16 [医药卫生—人体生理学]
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参考文献29

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听力学及言语疾病杂志
2014年 第3期

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