趋化因子eotaxin在慢性鼻窦炎鼻腔分泌物中的意义

Eotaxin in the nasal secretions of chronic sinusitis patients and its implication

目的慢性鼻窦炎在临床上虽能得到有效治疗,但复发率高仍是一大特点,且疾病的发病机制还不明确。文中探讨嗜酸性粒细胞(eosinophil,EOS)趋化因子eotaxin在慢性鼻窦炎鼻腔分泌物中的分布及意义。方法取40例鼻腔分泌物标本,15例为慢性鼻窦炎伴鼻息肉组,15例为慢性鼻窦炎不伴鼻息肉组,10例为正常对照组。使用酶联免疫吸附法(ELISA)检测eotaxin的浓度。结果鼻腔分泌物eotaxin的平均浓度慢性鼻窦炎伴鼻息肉组为(468.82±440.64)pg/mL,慢性鼻窦炎不伴鼻息肉组为(443.85±334.68)pg/mL,正常对照组为(149.23±49.01)pg/mL。慢性鼻窦炎伴鼻息肉组及慢性鼻窦炎不伴鼻息肉组鼻腔分泌物eotaxin浓度均比正常对照组鼻腔分泌物eotaxin浓度显著升高,差异有统计学意义(P<0.05)。结论 EOS趋化因子eotaxin在慢性鼻窦炎鼻腔分泌物中高表达,可能在慢性鼻窦炎的发病过程中起重要作用。

Objective Chronic sinusitis can be effectively treated clinically,but its recurrence rate is high and its pathogenic mechanism remains unclear.This article investigates eotaxin in the nasal secretions of chronic sinusitis patients and its implication.Methods Forty nasal secretion samples were collected from 15 cases of chronic rhinosinusitis with nasal polyps （CRSwNP）,15 cases of chronic rhinosinusitis without nasal polyps （CRSsNP）,and 10 normal control subjects.The concentration of eotaxin was measured by ELISA.Results The average concentrations of eotaxin in the CRSwNP,CRSsNP and normal control groups were （468.82 ± 440.64）,（443.85 ± 334.68） and （149.23 ± 49.01） pg/mL,respectively,significantly higher in the former two groups than in the latter one （P 〈 0.05）.Conclusion Highly expressed eotaxin may play an important role in the occurrence of chronic sinusitis.