中西药相互作用的药代动力学机制研究进展

Advancement in pharmacokinetic mechanisms of herb-drug interaction

近年来,中西药联合应用日益增多,引起诸多药物相互作用和不良反应。药物代谢酶和转运体在药物的体内代谢和处置过程中发挥重要的作用,中西药联用不仅会改变药物的理化性质和人体的生理特性,而且可以调节药物代谢酶和转运体的表达和功能,进而产生药动学相互作用,引起药物疗效的改变。本文对中西药相互作用的药动学基础及其评价方法进行总结,旨在为中西药的联合应用和研究提供参考。

Recently, there is a dramatic increase in the combination use of traditional Chinese medicine and western drug, causing various drug interactions and adverse effects. This combination can not only change physiochemical properties of the related drugs and physiological nature of human body, but regulate expression and function of drug metabolizing enzymes and transporters, which play key role in drug metabolism and disposition in vivo. Pharmacokinetic interaction then takes place frequently, together with alteration in clinical outcome. The paper summarizes the pharmacokinetics and assessment approaches of herb-drug interaction, acting as a reference for practical use and research.