子宫内膜癌中MDM2和p21的表达及恶性程度的相关性分析

Expression of MDM2 and p21 in endometrial carcinoma and the correlation with its severity

目的检测子宫内膜癌组织中MDM2和p21的表达情况,探讨MDM2和p21在子宫内膜癌组织中存在及临床意义。方法采用传统的免疫组织化学S-P法检测子宫内膜癌、正常子宫内膜组织中两者的表达情况并进行统计学分析。结果子宫内膜癌组织中MDM2和p21表达定位于细胞核,其阳性表达率分别为73%(66/90)和23%(21/90),与正常子宫内膜组织比较有显著性差异(P<0.05);两者在子宫内膜癌临床病理指标中的表达水平有显著性差异(P<0.05);在子宫内膜癌组织中MDM2和p21表达呈显著负相关性。结论 MDM2和p21在子宫内膜癌表达水平的高低,可以反映出子宫内膜癌的恶性程度,为临床对子宫内膜癌预后判断具有一定的指导意义。

Objective It is to determine the expression of p21 and MDM2 in the tissue of endometrial carcinoma and to discuss the clinical significance of MDM2 in the tissue of this disease. Methods The expressions of p21 and MDM2 in endometrial cancer and normal endometrial tissue was detected by immunohistochemistry S - P and the results were analyzed with statistical method. Results The expressions of p21 and MDM2 were located in cell nucleus, and the positive expression rates were 73% （66/90） and 23% （21/90） respectively which were significantly higher than that in normal endometrial tissue （P 〈 0.05 ）. Both of their expressions in endometrial cancer had statistically significant differences （ P 〈 0.05 ）. In endometrial carcinoma, the expressions of p21 and MDM2 were negatively correlated with each other （ P 〈 0.05 ）. Conclusion The high or low expressions of p21 and MDM2 in endometrial carcinoma can reflect the malignant degree of carcinoma of endometrium, and has a certain guiding significance for the diagnose of prognosis of this disease.