miR-572在胃癌组织中的表达

Expression of miR- 572 in gastric carcinoma

目的观察miR-572在胃癌及配对正常胃组织中的表达情况及差异性。方法利用实时荧光定量PCR技术检测26例胃癌组织及其正常胃黏膜组织中miR-572的表达,并分析其与临床病理资料的关系。结果与配对正常胃黏膜组织比较,miR-572在14例胃癌组织中呈高表达,在12例胃癌组织中呈低表达。miR-572在胃癌组织中的表达均高于正常胃黏膜组织(P<0.05);胃癌组织中不同年龄、性别、临床分期、组织学类型、分化程度和有无淋巴结转移之间miR-572的表达差异无统计学意义(P>0.05);而胃癌组织中腺癌、低分化、低分期和淋巴结转移者miR-572呈高表达的趋势。结论 miR-572在胃癌组织中高表达,可能与胃癌发生发展有关,但其临床病理学意义和具体作用机制有待进一步探讨。

Objective To probe the expression and differences of miR -572 in gastric carcinoma and matched normal gastric tissues.Methods The expression of miR572 in 26 biopsies were tested by using real -time quantitative PCR and then to analyze the relationship between the expression and the clinic opathological data .Results Compared with matched normal gastric tissue , the miR-572 showed a high expression in 14 cases of gastric carcinoma and a low ex-pression in 12 cases of gastric carcinoma .The expression of miR-572 in gastric carcinoma are higher than normal mucosa （P〈0.05）.There are no significant differences between/among ages, genders, clinical stages, histological types, de-grees of differentiation and lymph node metastasis or not （P〉0.05）.However there is a trend that miR -572 expressed highly in adenocarcinoma , poorly differentiated , low stage and metastasis groups .Conclusion miR-572 is highly ex-pressed in gastric cancer may be related to the occurrence and development of gastric cancer ; but its clinicopathological significance and specific mechanism should be further explored .