二肽基肽酶Ⅳ抑制剂对非酒精性脂肪肝病的影响被引量：3

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摘要二肽基肽酶Ⅳ（ DPP-4）抑制剂通过抑制DPP-4对肠促胰岛素的水解，增强肠促胰岛素的体内半衰期，发挥降糖效用，是当前新型抗糖尿病药物的研究热点之一。在临床观察中越来越多的证据表明，对合并有非酒精性脂肪肝病（NAFLD）的2型糖尿病（T2DM）患者使用DPP-4抑制剂单药或联合干预治疗后，在血糖控制较理想的同时，血脂、肝功能也有较明显的改善［1-2］。目前有不少的基础研究聚焦于探讨DPP-4抑制剂改善NAFLD病情可能的作用机制。鉴于T2DM与NAFLD同时属于代谢综合征的组分，两者有共同的胰岛素抵抗作用机制，考虑NAFLD病情的改善，部分得益于DPP-4抑制剂对肠促胰岛素（GLP-1／GIP）的保护，血糖的良好控制，胰岛素抵抗改善后脂肪分解减少；

作者刘艳陈容平张振陈宏

机构地区南方医科大学珠江医院内分泌科

出处《广东医学》 CAS CSCD 北大核心 2014年第9期1438-1440,共3页 Guangdong Medical Journal

关键词二肽基肽酶Ⅳ抑制剂非酒精性脂肪肝病胰岛素抵抗作用 NAFLD 肠促胰岛素抗糖尿病药物 T2DM 血糖控制

分类号 R977.15 [医药卫生—药品]

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