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DEK原癌基因在星形细胞肿瘤中的表达及意义 被引量：2

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摘要 目的检测星形细胞肿瘤组织中DEK的表达并分析其与星形细胞肿瘤病理分级之间的关系。方法应用免疫组化技术并用图像分析系统检测各级别星形细胞肿瘤组织及正常脑组织中DEK的表达水平。结果各组免疫组化染色阳性率分别为:肿瘤组织(96.88%),其中低级别肿瘤组织(92.86%),高级别肿瘤组织(100.00%),正常脑组织(40.00%);免疫组化染色强度分别为:低级别肿瘤组织(16.41±6.43),高级别肿瘤组织(34.88±14.61),正常脑组织(10.61±1.94)。DEK在肿瘤组织中的表达显著高于其在正常脑组织中的表达(P<0.05)。结论 DEK的过表达与星形细胞肿瘤的发生密切相关,并且与肿瘤的病理分级也密切相关;DEK表达改变,为星形细胞肿瘤临床诊断、治疗和预后判断提供了新思路。
作者 冯天达 刘云会 李振
机构地区 中国医科大学附属盛京医院神经外科
出处 《广东医学》 CAS CSCD 北大核心 2014年第10期1584-1586,共3页 Guangdong Medical Journal
基金 辽宁省教育厅科研项目(编号:L2010643)
关键词 星形细胞肿瘤 DEK 免疫组化 病理分级
分类号 R730.264 [医药卫生—肿瘤]
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参考文献11

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共引文献3

同被引文献32

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引证文献2

二级引证文献7

广东医学
2014年 第10期

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