血清降钙素原预测社区获得性肺炎病情严重程度的临床研究

Clinical study of serum procalcitonin to predict severity in elderly patients with community-acquired pneumonia

目的：探讨血清降钙素原在评估社区获得性肺炎（ CAP）病情严重程度的临床价值。方法收集2011年1月~2012年12月在西丽人民医院接受治疗的CAP患者80例，分≥65岁组50例；〈65岁组30例，评价两组患者血清降钙素原、C-反应蛋白、白细胞计数、CURB-65和肺炎严重程度指数（ PSI ）之间的相关性。结果血清降钙素原（ PCT）与CURB-65、PSI在总体上具有正相关性。血清降钙素原和CURB-65在≥65岁组CAP中尤其具有显著的正相关（r=0．408）。C-反应蛋白或白细胞水平与CAP严重程度之间的相关性较低。结论血清降钙素原比C-反应蛋白、白细胞计数更有助于临床预测CAP的严重程度，尤其是对于年龄大于65岁的老年患者。

Objective To evaluate the clinical value of procalcitonin as a predictor of severity in patients with community-acquired pneumonia （ CAP） . Methods 80 patients with CAP were divided into two groups （≥65 years, n=50; 〈65 years, n=30）. Their procalcitonin, C-reactive protein （CRP）, white blood cell, confusion, uremia, respiratory rate, blood pressure, CURB-65 and pneumonia severity of index （ PSI） were recorded. Results The level of procalcitonin was positively correlated with CURB-65 and PSI, which was especially stronger in the elderly group （r=0. 408）. The correlation between the levels of CRP or WBC and CAP severity was low. Conclu-sion The level of procalcitonin is more useful than the levels of CRP or WBC to predict the severity of CAP.