降钙素原检测在AECOPD抗菌治疗中的价值

Value of procalcitonin detection in antimicrobial therapy of AECOPD patients

目的探讨降钙素原检测在AECOPD抗菌治疗中的临床价值。方法选取本院诊治的AECOPD患者104例,根据治疗方案分为两组,52例患者参考临床症状行抗菌治疗为对照组,52例患者参考降钙素原水平行抗菌治疗为观察组,比较两组患者的临床指标、抗菌疗程、治疗效果、预后情况。结果观察组患者抗生素使用时间、住院时间均明显小于对照组,观察组患者抗生素使用率、二重感染率均明显低于对照组(P<0.05)。两组患者降钙素原、白细胞计数、C反应蛋白、病情加重率、死亡率、临床有效率等差异均无统计学意义(P>0.05)。结论在AECOPD抗菌治疗中,降钙素原检测可明显减少抗生素的使用率,减少抗生素使用时间,减少住院时间,避免滥用抗生素。

Objective To investigate the clinical value of procalcitonin detection in antimicrobial therapy of AECOPD patients. Methods 104 patients with AECOPD were randomly divided into two groups. The control group was treated with antimicrobial therapy according to clinical symptoms, and the observation group was treated with an-timicrobial therapy based on procalcitonin. The clinical indicators, antibacterial treatment and prognosis were com-pared between the two groups. Results The improvement of the duration of antibiotic use and hospital stay was more pronounced in the observation group than in the control group （P〈0. 05）. There was no significant difference in pro-calcitonin, white blood cell counts, C reactive protein, illness rate, mortality and clinical efficiency in the two groups （P〉0. 05）. Conclusion Procalcitonin detection can reduce antibiotic use obviously, which can also reduce the duration of hospital stay and avoid abuse of antibiotics in the treatment of AECOPD patients.