壮医通路酒皮肤毒性动物实验研究

Animal experimental study of dermal toxicity of Zhuangyi Tonglu Medicinal Liquor

目的观察实验家兔皮肤接触壮医通路酒后的毒性反应。方法以实验家兔为试验动物,选取体重(2.5±0.25)kg的家兔按雌雄各半标准随机分组并造模,用壮医通路酒涂于创面,以米酒作对照,观察各组皮肤反应。结果与对照组比较,用药后实验用药各组家兔的正常皮肤和破损皮肤均无急性毒性、长期毒性及皮肤刺激反应,并且实验用药组与对照组对比无明显差异(P>0.05)。结论壮医通路酒皮肤局部用药治疗痹证有较好的安全性。

Objective To observe toxic reactions in the experimental rabbits after skin touching the Zhuangyi Tonglu Medicinal Liquor.Methods The experimental rabbits weighing （2.5 ±0.25）kg were used as testing animal, then randomly divided into groups and molded according to the half genders standard .Each experimental groups were smeared Zhuangyi Tonglu Medicinal Liquor onto the wound or the normal skin while the control group was smeared rice wine.Dermal reactions of different groups were observed .Results The normal and wounded skin of rabbits in different groups showed no acute toxicity and long term toxicity , and Zhuangyi Tonglu Medicinal Liquor did not cause dermal irritation of rabbits .The experimental groups showed no significant difference compared with the control group （ P〉0.05） .Conclusion Treating arthralgia syndrome with Zhuangyi Tonglu Medicinal Liquor by the means of topi -cal skin smearing has reasonable security .