丹红注射液联合阿托伐他汀钙治疗老年腔隙性脑梗死的临床研究

The curative effect observation of Danhong injection combined with atorvastatin calcium in the treatment of lacunar cerebral infarction of the elderly

目的：观察丹红注射液联合阿托伐他汀钙治疗老年腔隙性脑梗死的临床疗效。方法收集2009年2月至2013年5月本院内科住院患者125例，采用数字随机表法将患者随机分为两组，对照组60例在对症支持治疗基础上加用阿托伐他汀钙，治疗组65例在对照组治疗基础上加用丹红注射液，治疗14 d后比较两组的临床疗效、神经功能缺损程度、血液流变学变化情况。结果治疗后治疗组总有效率为89.2%（58/65），对照组为71.7%（43/60），两组总有效率比较，差异有统计学意义（χ2＝7.283，P＜0.05）。治疗组治疗后神经功能缺损程度评分、全血黏度（高切）、全血黏度（低切）、血浆黏度、纤维蛋白原[（16.24±4.63）分、（3.62±0.64）mPa·s、（8.07±2.45）mPa·s、（1.61±0.30）mPa·s、（2.76±0.28）g/L]均较同组治疗前[（25.87±8.25）分、（5.41±1.20）mPa·s、（11.34±3.28）mPa·s、（2.15±0.38）mPa·s、（4.24±0.35）g/L]降低（P＜0.05），且疗效优于对照组[（22.17±7.38）分、（4.73±0.85）mPa·s、（9.86±3.26）mPa·s、（2.05±0.33）mPa·s、（3.94±0.35）g/L，P＜0.05]。结论丹红注射液联合阿托伐他汀钙可有效改善老年腔隙性脑梗死患者的神经功能缺损程度和血液流变学指标。

Objective To observe the clinical curative effect of Danhong injection combined with atorvastatin calcium in the treatment of lacunar cerebral infarction of the elderly.. Methods 125 elderly patients with lacunar cerebral infarction were randomly recruited into two groups, a control group（n=60 cases） was treated with atorvastatin calcium on the basis of conventional symptomatic treatment, and an observation group （n=65 cases） was treated with Danhong injection combined with atorvastatin calcium on the basis of conventional symptomatic treatment, the courses of two groups were 14 d. The clinical curative effect, the degree of nerve function defect score, the changes of hemorheology of two groups before and after the treatment were compared. Results The total effective rate of the observation group（89.2%）was significantly higher than that of the control group（71.7%）（P〈0.05）. The degree of nerve function defect score（16.24±4.63）of observation group after treatment improved significantly better than that of control group（22.17±7.38）, P〈0.05, and the whole blood viscosity（high）, whole blood viscosity（low）, plasma viscosity and fibrinogen [（3.62±0.64）mPa·s,（8.07±2.45）mPa·s, （1.61±0.30）mPa·s, （2.76±0.28）g/L]decreased significantly than that of the control group[（4.73±0.85）mPa·s, （9.86±3.26）mPa·s, （2.05±0.33）mPa·s,（3.94±0.35）g/L], P〈0.05. Conclusion The treatment of Danhong injection combined with atorvastatin calcium for elderly lacunar cerebral infarction had a good therapeutic effect. It could improve nerve function defect degree and blood rheology indexes.