填精补肾养血疏肝方口服配合中药外敷治疗卵巢早衰的临床研究

Curative effect observation of premature ovarian failure treated by oral taking traditional Chinese medicine with functions of tonifying kidney, nourishing blood and soothing liver and external application

目的：探讨中药填精补肾养血疏肝方口服、外敷治疗卵巢早衰的临床疗效。方法收集2009年7月至2013年7月中国中医科学院西苑医院妇科门诊符合肝肾阴虚型卵巢早衰诊断标准的患者40例，口服填精补肾、养血疏肝中药，加温经通络中药外敷治疗3个月，比较治疗前后月经情况、症状改变、卵泡刺激素（FSH）、黄体生成素（LH）及雌二醇（E2）的变化。结果①治疗后月经积分较治疗前下降，差异有统计学意义（t＝5.694，P＜0.01）；②治疗后症状积分较治疗前下降，差异有统计学意义（t＝21.828，P＜0.01）；③治疗后FSH、LH下降，E2水平升高，与治疗前比较差异均有统计学意义（P均＜0.05）。④临床总有效率为92.5%（37/40）。结论填精补肾、养血疏肝药可改善肝肾阴虚型卵巢早衰患者的临床症状，降低血清FSH、LH，提高E2水平，改善卵巢功能。

Objective To evaluate the clinical efficacy of oral taking traditional Chinese medicine with functions of tonifying kidney, nourishing blood and soothing liver and external application treatment of premature ovarian failure（POF）. Methods 40 patients of deficiency of liver-yin and kidney-yin type POF in Gynecology Department of Xiyuan Hospital CACMS from July 2009 to July 2013 were collected and administrated with traditional Chinese medicine with functions of tonifying kidney, nourishing blood and soothing liver and external treatment for 3 months. The changes of menstruation situation, symptoms and serum sex hormone were compared before and after the treatment. Results ① Menstruation integral were reduced after the treatment, showing a statistical significance compared with those before the treatment（t=5.694,P〈0.01）. ② Symptoms integral were reduced after the treatment, showing a statistical significance compared with those before the treatment（t=21.828,P〈0.01）. ③ Serum FSH, LH were decreased and Serum E2 were increased after the treatment,showing a statistical significance compared with those before the treatment（P〈0.05）. ④ The total effective rate was 92.5%（37/40）. Conclusion Traditional Chinese medicine with functions of tonifying kidney, nourishing blood and soothing liver are effective for treating POF. These methods had proven to improve ovarian function by decreasing high level of FSH and LH, whereas enhancing the estrogen level, and therefore promote menstruation cycle.