自拟麻杏蝉苏汤治疗小儿干咳夜咳疗效分析

Curative effect observation on self-designed Maxing-Chansu decoction in treating children cough or night cough

目的：观察自拟方麻杏蝉苏汤治疗小儿干咳夜咳的临床疗效。方法收集2010年1月至2013年6月湖北省十堰市郧县中医院就诊的干咳夜咳患儿100例，按随机数字表法将患儿随机分为两组，均采用常规治疗（包括抗感染、雾化吸入及对症治疗），对照组40例在常规治疗基础上口服非那根口服液；治疗组60例在常规治疗基础上加服自拟方麻杏蝉苏汤。两组均治疗7 d，观察患儿咳嗽情况、病程及不良反应。结果治疗组总有效率为100%（60/60），对照组为85%（34/40），两组总有效率比较，差异有统计学意义（χ2＝15.2，P＜0.05）。治疗组患儿气促缓解、咳嗽消失、肺部啰音消失时间[分别为（2.5±0.6）d、（4.1±0.8）d、（4.2±0.7）d]短于对照组[分别为（5.8±0.5）d、（8.8±0.9）d、（6.7±0.8）d，P＜0.05]。治疗组支气管炎患儿、支气管肺炎患儿、咳嗽变异性哮喘患儿平均住院日[分别为（4.3±0.4）d、（7.8±0.5）d、（6.5±0.5）d]低于对照组[分别为（7.3±0.5）d、（10.8±0.7）d、（9.5±0.6）d，P＜0.05]。结论自拟方麻杏蝉苏汤可明显改善干咳夜咳患儿气促、咳嗽、肺部啰音等症状，缩短患儿治疗时间。

Objective To observe the clinical efficacy and adverse reactions of self designed Maxing-Chansu decoction in the treatment of infantile cough and night cough. Methods 100 dry cough and night cough patients were randomly divided into two groups, with 60 patients in a treatment group, 40 patients in a control group. The control group was treated with conventional treatment including anti infection, inhalation, and symptomatic treatment（with promethazine oral liquid as the positive control）. The treatment group was treated with Chinese medicine Maxing-Chansu decoction on the basis of the control group. The course of disease, cough and adverse reactions were observed in both groups. Results The total effective rate was 100%and 85%in the treatment group and the control group respectively, with statistical difference（χ2=15.2,P〈0.05）. The time of children’s anhelation remission, cough disappearance, lung rale disappearance in the treatment group was（2.5± 0.6）d,（4.1±0.8）d, and（4.2±0.7）d respectively, which were shorter than those（5.8±0.5）d,（8.8±0.9）d, （6.7±0.8）d, and P〈0.05 in the control group. The average hospitalization date of treating children with bronchitis, bronchopneumonia, and cough variant asthma was（4.3±0.4）d,（7.8±0.5）d, and（6.5±0.5）d, which were shorter than those（7.3±0.5）d,（10.8±0.7）d,（9.5±0.6）d in the control group, P〈0.05. Conclusion The traditional Chinese medicine Maxing-Chansu decoction in treating children cough and night cough was quick, reliable and with stable curative effect, which was worth further study and promotion.