摘要
加兰他敏类生物碱是氢化二苯并呋喃类生物碱的重要组成部分.它们独特的结构、良好的生物活性和前景广阔的药用价值吸引了众多化学家和药物学家的兴趣.其合成难点是其中的含芳基手性全碳季碳的构筑.本综述旨在阐述到目前为止加兰他敏类生物碱的不对称合成方法,根据合成路线中手性季碳的构筑方式分类进行说明,并尝试对每种合成方法进行评述.
Galanthamine-type alkaloids are an important type of hydrodibenzofuran alkaloids. Their unique intriguing structures, significant biological activitives and pharmacological potential have attracted much attention of chemists and pharmacologists. The major challenge for their synthesis is how to construct the aryl-substituted all-carbon quaternary stereogenic center. In this paper, current strategies for asymmetric synthesis of galanthamine-type alkaloids are reviewed, and the different methods to prepare the quaternary carbon are discussed. The features of different strategies are also commented.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2014年第5期852-864,共13页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21302061)
中国博士后科学基金(Nos.2013T60318
2012M510130)
吉林省科技发展计划(No.20140520084JH)资助项目~~
关键词
加兰他敏
力可拉敏
不对称合成
手性全碳季碳
galanthamine
lycoramine
asymmetric synthesis
all-carbon quaternary stereogenic center
