基于缺电子烯胺交叉氨化过程的多组分反应研究进展

Recent Advances on Multicomponent Reactions Based on the Transamination Process of Electron Deficient Enamines

缺电子烯胺结构上含有多个不同活性的亲核和亲电反应位点,同时双键本身可以作为烯键给予体参与反应,因此可以通过各种亲核、亲电以及环加成等转化广泛应用于有机合成反应.综述结合我们自己小组的研究工作和兴趣,对基于缺电子烯胺如烯胺酮、烯胺酯等和含胺基试剂包括铵、胺、烯胺、脲和硫脲等之间的交叉氨化为关键转化,并和其它底物发生串联转化的多组分反应研究进展进行了总结.

Electron deficient enamines bear several different nucleophilic and eletrophilic sites in their structures, they can also serve as donors of C ：C bonds in organic reactions. Therefore, electron deficient enamines have been broadly employed in organic synthesis via various nucleophilic, electrophilic transformation and cycloaddition. Based on the research interest and works of our group in the chemistry of electron deficient enamines, the research advances on multicomponent reactions （MCRs） are reviewed based on the transamination of electron deficient enamines with ammomium, amines, enamines, ureas and thioureas as key transformation.