方便、有效的方法合成2-氨基-1,3-二氰基-4-芳基-5,6,7,8,9,10,11,12,13,14-十氢苯并[12]轮烯衍生物

A Facile and Efficient Synthesis of 2-Amino-1,3-dicarbonitrile-4-aryl-5,6,7,8,9,10,11,12,13,14-decahydrobenzo[12]annulene Derivatives

芳香醛、环十二酮和丙二腈在苄胺存在下于95%乙醇中反应,方便地合成了一系列2-氨基-1,3-二氰基-4-芳基-5,6,7,8,9,10,11,12,13,14-十氢苯并[12]轮烯衍生物,苄胺作为碱催化此类的反应还未见报道.产物的结构经过红外、核磁和高分辨质谱确定.本方法具有反应时间短、容易操作、产率高等优点,是合成此类化合物的一条有效途径.

A facile and efficient synthesis of 2-amino-1,3-dicarbonitrile-4-aryl-5,6,7,8,9,10,11,12,13,14-decahydrobenzo[12]-annulene derivatives by the reaction of aromatic aldehydes, cyclododecanone, and malononitrile in the presence of benzylamine in 95% EtOH is reported. Benzyamine as base to catalyze this kind of reaction has not been reported. This protocol has the advantages of short reaction time, mild conditions, and easy work-up. The products were identified by IR, 1H NMR and HRMS. The reported method is the efficient approach for the synthesis of these compounds.