LTA单核苷酸多态性与胃癌易感性关系的研究进展

Research progress on the correlation of LTA single nucleotide polymorphism with the susceptibility of gastric cancer

尽管世界范围内胃癌的发病率和死亡率有下降趋势,但是近年来我国胃癌发病率和死亡率仍在逐渐上升,已经成为影响人们生存质量的主要因素之一。胃癌的发病机制与多种因素有关,涉及基因多态性、炎性细胞因子及生化机制等,其中淋巴毒素-α(LTA)基因单核苷酸多态性成为近年来研究胃癌致病机理的热点之一。目前发现LTA rs909253(A/G)、rs1041981(C/A)、rs2229094(T/C)、rs746868(G/C)等与胃癌患病风险有一定关联,但尚未得出一致性的结论。本文就目前LTA基因多态性与胃癌易感性的研究进展进行综述。

Although the morbidity and mortality of gastric cancer is on the decline around the world,it is still rising in China recently and has become one of main factors that influences on the quality of people′s life.The pathogenesis of gastric cancer is associated with various factors,involving in gene polymorphism,inflammatory cytokines,biochemical mechanisms and so on.In particular,lymphotoxin-alpha（LTA）gene single nucleotide polymorphism has been a hot spot in the research of gastric carcinogenesis in recent years.While LTA rs909253（A/G）,rs1041981（C/A）,rs2229094（T/C）,rs746868（G/C）and so on have some associations with gastric cancer,there is no consistent result.This article reviews the current progress in the relationship between LTA gene polymorphism and the susceptibility of gastric cancer.