阿莫西林与阿米卡星对沙门菌的体外联合药敏试验

In vitro drug sensitivity test on Salmonella amoxicillin and Amikacin

目的:探讨阿莫西林与阿米卡星联合抗菌效果及沙门菌耐药性。方法:采用微孔板将不同浓度阿莫西林及阿米卡星药物中分别加入100μg/ml稀释菌液,记录菌液对单一阿莫西林及阿米卡星及联合给药耐药性。结果:阿莫西林与阿米卡星联合给药后,沙门菌耐药性所需浓度远小于单一使用上述药物,对比结果差异有统计学意义(P<0.05)。结论:临床治疗沙门菌所致感染性疾病可采用阿莫西林联合阿米卡星给药方法,提高临床疗效,保障患者生活质量及生命安全,值得临床推广应用。

Objective Amoxicillin and Anfikacin combined antimicrobial resistance ofSalmonella enteritidis and effect.Methods Using 100 μ g/ml diluted bacteria were added to microtiter plate with different concentration of amoxicillin and Amikacin drugs,record the bacteria liquid onsingle amoxicillin and Amikacin and coadministration of drug resistance.Results Arnoxicillin combined with Amikacin after administration,the antibiotic resistance of Salmonella required concentration is far less than the single use of these drugs,the results were statistically significant（P 〈 0.05）.Conclusion Clinical treatment of Salmonella infectious diseases induced by amoxicillin for the Amikacin administration,improve the clinical efficacy, guarantee the qualityand safety of patients,is worthy of clinical application.