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缬沙坦对糖尿病大鼠内皮细胞功能及氧化应激的影响 被引量：1

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摘要 以链脲佐菌素建立糖尿病大鼠模型,缬沙坦干预治疗12周,光镜下观察大鼠胸主动脉组织结构,并用RT-PCR方法测定血管紧张素II(AngII)mRNA表达平,用Elisa方法测定血清血管假血友病因子(VWF)、内皮素-1(ET-1)、8脱氧鸟酐(8-OHdG)、超氧化物歧化酶(SOD)含量。结果缬沙坦干预治后,8OHdG含量降低,SOD活性增加;ET-1、VWF含量均降低;光镜下观察大鼠胸主动脉病理损伤得到改善。结论氧化应激和肾素血管紧张素(RAS)系统的紊乱参与了糖尿病大鼠的胸主动脉病变过程,缬沙坦通过阻断RAS系统活性,下调AngII基因表达,降低氧化应激反应,从而减轻血管内皮细胞损伤,可能是缬沙坦保护胸主动脉内皮功能的基本机制之一。
作者 良介 汪晓霞 荀光 张希尧 王婵媛 武小碧
机构地区 哈尔滨医科大学附属第四医院内分泌代谢科
出处 《实用糖尿病杂志》 2014年第3期62-64,共3页 Journal of Practical Diabetology
关键词 糖尿病 氧化应激 缬沙坦 内皮功能
分类号 R589.1 [医药卫生—内分泌]
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参考文献6

  • 1N. Sattar.Revisiting the links between glycaemia, diabetes and cardiovascular disease[J].Diabetologia.2013(4)
  • 2Chong Tian,Rui Zhang,Xiaolei Ye,Changhui Zhang,Xin Jin,Yukio Yamori,Liping Hao,Xiufa Sun,Chenjiang Ying.Resveratrol ameliorates high-glucose-induced hyperpermeability mediated by caveolae via VEGF/KDR pathway[J].Genes & Nutrition.2013(2)
  • 3Liwei Zhang,Baihua Chen,Luosheng Tang.Metabolic memory: Mechanisms and implications for diabetic retinopathy[J].Diabetes Research and Clinical Practice.2011(3)
  • 4Lawrence A. Leiter,Richard Z. Lewanczuk.Of the renin-angiotensin system and reactive oxygen species[J].American Journal of Hypertension.2005(1)
  • 5Krzysztof Siemianowicz,Tomasz Francuz,Jan Gminski,Alicja Telega,Marcin Syzdól.Endothelium dysfunction markers in patients with diabetic retinopathy[J].International Journal of Molecular Medicine.2005(3)
  • 6Peter Zahradka,Jeffrey P. Werner,Shelly Buhay,Brenda Litchie,Gail Helwer,Shawn Thomas.NF-κB Activation is Essential for Angiotensin II-dependent Proliferation and Migration of Vascular Smooth Muscle Cells[J].Journal of Molecular and Cellular Cardiology.2002(12)

同被引文献15

  • 1Atkins GB, Simon DI. Interplay between NF-KB and Kruppel- like factors in vascular inflammation and atherosclerosis : location, location, location [ J ]. J Am Heart Assoc, 2013,2 ( 3 ) : 290-291.
  • 2Luvai A, Mbagaya W, Hall AS, et al. Rosuvastatin : a review of the pharmacology and clinical effectiveness in cardiovascular disease [ J]. Chn Med Insights Cardiol, 2012,6(2) :17-33.
  • 3Nagy N, Melchior-becker A, Fischer JW, et al. Long-term treatment with the AT-l-receptor antagonist telmisartan inhibits biglycan accumulation in murine atherosclerosis[ J]. Basic Res Cardiol, 2010, 105(1) :29-38.
  • 4Cybulsky MI, Won D, Haidari M. Leukocyte recruitment to atherosclerotic lesions[ J ]. Can Jcardiol, 2004,20 ( suppl B ) : 24B- 28B.
  • 5Seneviratne AN, Sivagurunathan B, Monaco C. Toll-like receptors and maerophage activation in athemsclemsis [ J ]. Clin Chim Acta, 2012, 413(1-2) :3-14.
  • 6Yokoi T, Fukuo K, Yasuda O. Apoptosis signal regulating kinasel mediates cellular senescence induced by high glucose in endothelial cells[ J]. Diabetes, 2006,55 (6) : 1660-1665.
  • 7E1-Osta A, Brasaeehio D, Yao D, et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent nonnoglycemia[ J]. J Exp Med, 2008,205 ( 10 ) : 2409- 2417.
  • 8Piga R, Naito Y, Kokura S, et al. Short-term high glucose exposure induces monocyte-endothelial cells adhesion and transmigration by increasing VCAM-1 and MCP-1 expression in human aortic endothelial cells[ J]. Athemsclemsis. 2007.193 (2) ,328-334.
  • 9Nissen SE, Tuzcu EM, Schoenhagen P, et al. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease [ J ]. N Engl J Med, 2005,352( 1 ) :29-38.
  • 10孙丰雷.高血糖对血管内皮功能影响的研究进展[J].中西医结合心脑血管病杂志,2009,7(6):724-725. 被引量：7

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实用糖尿病杂志
2014年 第3期

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