血清MMP-11在甲状腺乳头状癌中的表达与临床意义

Expression and clinical significance of Serum MMP-11 in papillary thyroid carcinoma

目的:探讨血清基质金属蛋白酶-11(MMP-11)在甲状腺乳头状癌患者中的表达水平及其临床意义。方法:分别对30例甲状腺乳头状癌患者、30例甲状腺良性肿物患者及30例健康体检者血清使用酶联免疫吸附法(ELISA)检测其MMP-11抗体浓度。结果:甲状腺乳头状癌患者术前血清MMP-11抗体浓度均显著高于良性病变组和健康体检者,差异有统计学意义(P<0.05)。结论:甲状腺乳头状癌患者血清MMP-11表达水平较良性病变和健康体检者显著升高,因此,血清MMP-11检测可用于术前甲状腺结节的良、恶性鉴别,对甲状腺乳头状癌术前诊断存在实际的临床参考价值。

Objective：To investigate serum matrix metalloproteinase-11（MMP-11）expression in papillary thyroid carcinoma patients and its clinical significance. Methods：30 cases of patients,30 cases of papillary thyroid carcinoma in patients with benign thyroid tumor and 30 cases of healthy person serum by enzyme linked immunosorbent assay（ ELISA）to detect the MMP-11 antibody concentration. Results：In patients with papillary thyroid cancer serum MMP-11 antibody con-centrations were significantly higher than those of the benign group and healthy controls,the difference was statistically significant（P﹤0. 05）. Conclusion：The expression of thyroid papillary carcinoma of serum MMP-11 levels in patients with benign disease and healthy control subjects were significantly increased,therefore,serum MMP-11 assay can be used to identify benign,malignant thyroid nodules before surgery,for clinical reference value in preoperative diagnosis of papillary thyroid carcinoma has practical value.