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丁二酸酐与胺类化合物在碱性条件下的反应规律 被引量：2

The reaction law of succinic anhydride with amines under basic condition
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摘要 以吡啶为溶剂，110℃加热6 h的反应条件下，芳香伯胺与丁二酸酐反应，主要生成N-芳香取代丁二酰亚胺，最高收率73.2％；相反，脂肪伯胺与丁二酸酐反应，主要产物为N-取代丁二酸单酰胺，收率72.5％～81.7％．探讨了结构-反应活性关系，并提出可能的反应机理． Byheatingat110℃for6happliedpyridineassolvent,themajorproductsofaromatic primary amines with succinic anhydride were N-substituted succinimides. The maximum yield was 73.2%;On the contrary,the main products of fatty primary amines with succinic anhydride were N-sub-stituted succinic acid mono-amides.The yields were arranged from 72.5%to 81.7%.The structure-re-activity relationship has been studied.A putative mechanism was also put forward.
作者 杨健 陈河如
机构地区 暨南大学药学院中药及天然药物研究所广东广州 暨南大学广东省中药药效物质基础及创新药物研究重点实验室
出处 《暨南大学学报（自然科学与医学版）》 CAS CSCD 北大核心 2014年第3期320-324,共5页 Journal of Jinan University(Natural Science & Medicine Edition)
基金 国家自然科学基金项目(81172982) 广东省科技计划项目(2010A030100006)
关键词 丁二酰亚胺 丁二酸酐 环化 有机合成 succinimide succinicanhydride cyclization organicsynthesis
分类号 O629.7 [理学—有机化学]
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参考文献17

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二级参考文献9

同被引文献21

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暨南大学学报（自然科学与医学版）
2014年 第3期

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