舍曲林联合丁螺环酮治疗抑郁症伴性功能障碍对照研究

A control study of sertraline combined with buspirone in de-pression with sexual dysfunction

目的：探讨舍曲林联合丁螺环酮治疗抑郁症伴性功能障患者的临床疗效。方法将100例抑郁症伴性功能障碍患者随机分为两组，每组50例，两组均口服舍曲林治疗，观察组联合丁螺环酮合治疗，观察8周。采用汉密顿抑郁量表、抑郁自评量表评定抑郁状况，Olson婚姻质量问卷评定婚姻质量，性生活满意度量表评定性生活满意度。结果治疗后两组汉密顿抑郁量表、抑郁自评量表评分均较治疗前显著下降（P＜0．01），观察组较对照组下降更显著（P＜0．01）；两组Olson婚姻质量问卷评分均较治疗前显著升高（P＜0．01），观察组较对照组升高更显著（P＜0．01）；观察组性生活总满意率显著高于对照组（χ2＝7．48，P＜0．01）。结论舍曲林联合丁螺环酮治疗抑郁症伴性功能障患者效果显著，能显著提高患者的性生活满意度和婚姻质量，显著优于单用舍曲林治疗。

Objective To explore the efficacy of sertraline combined with buspirone in depression with sex-ual dysfunction .Methods A total of 100 depression patients with sexual dysfunction were randomly as-signed to two groups of 50 ones each ,both groups took orally sertraline ,observation group was plus bus-pirone for 8 weeks . Depression status was assessed with the Hamilton Rating Scale for Depression （HRSD） and Self-rating Depression Scale （SDS） ,marital quality with the Olson Marital Quality Question-naire （ENRICH） ,and sexual satisfaction with the Sexual Satisfaction Scale （SSS） .Results After treat-ment the HRSD and SDS scores of both groups lowered more significantly compared with pre-treatment （P〈0 .01） ,so did those in observation than in control group （P〈 0 .01）;the ENRICH scores of both groups heightened more significantly （P〈0 .01） ,so did those in observation than in control group （P〈0 .01）;sexual satisfaction was significantly higher in observation than in control group （χ2 = 7 .48 , P〈0 .01） .Conclusion Sertraline combined with buspirone has an evident effect in depression with sexual dys-function ,can notably improve sexual satisfaction and marital quality compared with single sertraline .