曲唑酮与氟西汀治疗围绝经期抑郁症对照研究

A control study of trazodone versus fluoxetine in perimenopa-usal depression

目的：探讨曲唑酮与氟西汀治疗围绝经期抑郁症的临床疗效和安全性。方法将72例围绝经期抑郁症患者随机分为两组，每组36例，研究组口服曲唑酮治疗，对照组口服氟西汀治疗，观察6周。于治疗前后采用汉密顿抑郁量表、汉密顿焦虑量表评定临床疗效，副反应量表评定不良反应。结果研究组治疗1周末汉密顿焦虑量表总分、汉密顿抑郁量表总分及睡眠因子分显著低于对照组（ P＜0．05）；治疗6周末研究组显效率86．1％、有效率94．4％，对照组分别为77．8％、94．4％，两组比较差异无显著性（χ2＝0．84、0，P＞0．05）。研究组失眠及焦虑不安发生率显著低于对照组（P＜0．05）。结论曲唑酮与氟西汀治疗围绝经期抑郁症疗效均显著，但曲唑酮能够较快改善患者的焦虑及睡眠状况，治疗依从性更好。

Objective To explore the efficacy and safety of trazodone versus fluoxetine in perimenopausal depression .Method Seventy-two patients with perimenopausal depression were randomly assigned to two groups of 36 ones each ,research group took orally trazodone and control group did fluoxetine for 6 weeks . Efficacies were assessed with the Hamilton Depression Scale （HAMD） and Hamilton Anxiety Scale （HA-MA ） before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale （TESS） .Results At the end of the 1st week the HAMA total ,HAMD total and sleep score were signifi-cantly lower in research than in control group （P〈0 .05）;at the end of the 6th week obvious effective and effective rate were respectively 86 .1% and 94 .4% in research and 77 .8% and 94 .4% in control group , which showed no significant differences （χ2 =0 .84 ,0 ;P〉0 .05） .The incidences of insomnia and dysphori-a were significantly lower in research than in control group （P〈0 .05） .Conclusion Both trazodone and fluoxetine have an evident effect in the treatment of perimenopausal depression ,but the former could im-prove patients’ anxiety and sleep status more rapidly and has better compliance .