麻痹性痴呆患者临床资料分析

Analyses of clinical data for dementia paralytica patients

目的：探讨麻痹性痴呆患者的临床表现、实验室检查、影像学特征，为早期诊断提供依据。方法对21例麻痹性痴呆患者的临床资料进行回顾性分析。结果本组患者均无自知力，并伴有精神病性症状、记忆力下降，部分患者伴有共济失调等症状；简易智力状态检查量表评分为（10＆#177;3）分，实验室检查梅毒螺旋体血凝试验及快速血浆反应素环状卡片试验均为阳性；其中13例患者行头颅C T检查，提示脑萎缩3例。结论麻痹性痴呆早期临床表现复杂多样，容易导致误诊误治，应详细询问病史，重视梅毒血清和脑脊液抗体检查，并结合影像学提高确诊率。

Objective To explore the clinical manifestations ,laboratory examina-tion and imaging characteristics of dementia paralytica （DP） patients in order to provide basis for early diagnosis .Methods Retrospective analyses of clinical data were carried out in 21 DP patients .Results All patients had no insight ,were accompanied with psychotic symptoms and hypomnesia ,and partial patients with ataxia and so on ;the MMSE score was 10 ＆#177; 3 ,both laboratory treponemal hemagglutination and rapid plasma reagin test were positive ;three of 13 patients performed brain CT suggested brain atrophy .Conclusion Early clinical manifestations DP patients are complicated and diversified ,result in diagnostic errors and mistreatment easily ;in order to improve con-firmed diagnosis rate case history should be carefully questioned ,serum and cerebrospinal fluid syphilis an-tibody examination valued ,and combined with imaging .