住院男性精神分裂症患者氯氮平应用状况调查

Clozapine application status of hospitalized male schizophren-ics

目的：了解氯氮平在住院男性精神分裂症中的应用状况。方法对120例住院男性精神分裂症患者应用氯氮平治疗状况进行调查分析。结果本组男性精神分裂症患者氯氮平使用率为65．0％，其中97．4％的病程≥5a，64．1％的经济状况较差（农村低保）；单一用药占38．5％，两药联用占55．1％，三药联用占6．4％；氯氮平联合第一代及第二代抗精神病药物的概率均为17．9％，联合情绪稳定剂的概率为20．5％。结论住院男性精神分裂症患者应用氯氮平的频率较高。氯氮平多用于病程≥5a，且经济状况较差的精神分裂症患者，以联合用药为主，临床医生应严格掌握用药适应证，注重患者的远期疗效及认知功能、社会功能的恢复。

Objective To survey clozapine application status of hospitalized male schizophrenics .Methods Time-point surveys of drug application status were conducted in 120 hospitalized male schizophrenics who were treated with clozapine .Results Clozapine use rate was 65 .0% in hospital-ized male schizophrenics ,97 .4% of them had course ≥ 5 years ,64 .1% did poor economic status （rural low-security）;single medication made up 38 .5% ,two drugs combination 55/1% and three 6 .4% ;proba-bility of clozapine plus first and second generation antipsychotic was 17 .9% ,that of plus stabilizer 20 .5% . Conclusion Clozapine use frequency is higher in hospitalized male schizophrenics .Clozapine is mainly used in patients whose courses are ≥ 5 years and who have poor economic status ,drug combination is main treatment method ,clinicians should master indication strictly ,pay attention to long-term efficacy , cognitive function and social function recovery .