脑脊液腺苷脱氨酶在小儿结核性脑膜炎中的诊断及疗效评估价值

THE DIAGNOSIS VALUE OF ADENOSTHE DEAMINASE IN THE CEREBROSPIHAL FLUID IN CHILDREN WITH TUBERCULOUS MENINGITIS AND DYMAMIC CHANGES OBSERVATION

目的评价脑脊液腺苷脱氨酶(ADA)在小儿结核性脑膜炎中的诊断价值及动态变化观察。方法应用P800全自动生化分析仪检测100例结脑患儿和35例非结脑患儿的脑脊液ADA活性。结果结脑患儿脑脊液ADA活性明显高于非结脑患儿,差异有统计学意义(p<0.01);结脑组治疗前后脑脊液ADA活性相比差异有统计学意义(p<0.01)。结论脑脊液ADA活性测定是鉴别结核性脑膜炎及非结核性脑膜炎的一个良好的辅助诊断指标,且ADA变化可作为结核性脑膜炎的治疗效果指标。

Objective To investigate the diagnosis value of ADA in the cerebrosoinal fluid of the children patients with the tuberculous meningitis and the Observation of dymamic changes. Methods the sample of CSF with100 TBM patients,35 non- TBM patients were detemined with P800 automatic biochemical analyzer. Results The lever of CSF ADA activity in the patients with the tuberculous meningitis was significantly higher than the control groups,the difference was significant（ p 〈0. 01）; tuberculous meningitis cerebrosoinal fluid ADA activity befor and after treament,the difference was significant（ p 〈0. 01）. Conclusion The CSF- ADA couble be used as a clinical assistant diagnosis of tuberculous meningitis in children,and the chang of ADA couble used as an indexes of treatment effect with tuberculous meningitis.