35例鸦胆子外用致药品不良反应/事件的文献分析

Literature Analysis of 35 Cases of Adverse Drug Reaction/Event Induced by Brucea Javanica for Topical Use

目的：探讨鸦胆子外用致不良反应/事件的一般规律，为临床合理用药提供参考。方法通过检索1958～2012年《中国期刊全文数据库》，对收集到的35例鸦胆子外用致不良反应/事件的文献报道进行统计分析。结果35例病例报告中急性过敏反应29例，通常发生在用药后60min内,18例发生在用药5min内，其中过敏性休克20例；发生急性眼部损伤4例，表现为眼部疼痛、异物感、畏光流泪、视物模糊、视力下降；发生表皮松解坏死型皮炎、右足背及右下肢肿胀各1例。结论鸦胆子外用可引起严重药品不良反应/事件，须加强其致药品不良反应/事件的研究及防治。

Objective To investigate the epidemiological characteristics of adverse drug reactions/event （ADR/ADE） induced by Brucea javanica. Methods With retrospective case study, analyzed 35 cases of ADR/ADE induced by Brucea javanica, which were searched from Chinese Journal Full-text Database between1958 and 2012. Results 29 cases were acute allergy, including 20 allergic shock cases. Acute allergy usually occurred in 60 min after drug treatment, 18 cases occurred in 5 min after drug treatment. 4 cases were acute eye injury, manifested as eye pain, foreign body sensation, photophobia, blurred vision and severe vision loss. Other clinical manifestations were epidermolytic necrotizing dermatitis（1case） and right lower limb swelling（1 case）. Conclusion Brucea javanica for topical use may induce serious ADR/ADE, which should be strengthened to observe and evaluate.