45例前列地尔的不良反应分析

Analysis of 45 Cases of Adverse Drug Reaction Induced by Alprostadil

目的：分析我院前列地尔所致不良反应的特点，为临床合理用药提供参考。方法收集2008～2012年度前列地尔所致不良反应报告，对患者性别、年龄、用药情况、不良反应表现、处理方法与结果等方面进行统计分析，归纳其不良反应特点。结果前列地尔不良反应报告45例，30岁以上居多，累及系统-器官主要为外周血管系统、皮肤和中枢神经系统，主要临床表现为静脉炎、皮疹、头晕、头痛，多数发生在用药0～3天后。结论应加强前列地尔不良反应的监测，及早预防，减少不良反应的发生。

Objective To analyze the adverse drug reaction（ADR） caused by alprostadil in our hospital and to provide reference to its rational use . Methods The cases of ADR by alprostadil reported in our hospital from 2008 to 2012 were collected. A statistical analysis was conducted based on gender, age, clinical manifestation, rescue strategies and prognosis of the ADR. Results For 45 cases collected, the ages of patients were mostly over 30, the primary ADRs related organs or systems were peripheral vascular system, skin and central nervous system. The main clinical mani-fes tations were phlebitis, rash, dizzy and headache, most appeared 0~3 days after dosing. Conclusion The moni toring for adverse reactions of alprostadil should be strengthened. Early prevention can reduce the incidence of adverse reactions.