合欢花乙酸乙酯部位化学成分研究

Chemical constituents from ethyl acetate extract of flower of Albizia julibrissin

该文对合欢Albizzia julibrissin干燥花序的乙酸乙酯萃取部位进行化学成分研究,采用硅胶,Sephadex LH-20,MCI GEL CHP-20P等柱色谱技术分离纯化,利用波谱数据(1H,13C-NMR,MS)进行结构鉴定,共分离和鉴定29个化合物,分别为8-hydroxy-2,6-dimethyl-2E,6Z-octadienoic acid(1),8-O-formyl-2,6-dimethyl-2E,6Z-octadienoic acid(1a),8-hydroxy-2,6-dimethyl-2E,6E-octadienoic acid(2),8-O-formyl-2,6-dimethyl-2E,6E-octadienoic acid(2a),(2E,6S)-2,6-二甲基-6-O-β-D-吡喃木糖基-2,7-辛二烯酸(3),clovan-2β,9α-diol(4),2β-O-formyl-clovan-9α-ol(4a),2β,9α-O-diformyl-clovan(4b),吐叶醇(5),(6S,9R)-roseoside(6),香草醛(7),4-O-乙基没食子酸(8),3-乙氧基-4-羟基苯甲酸(9),对-羟基苯甲醛(10),没食子酸(11),原儿茶酸(12),硬脂酸(13),软脂酸(14),2,3-dihydroxypropyl hexadecanoate(15),亚油酸(16),东莨菪内酯(17),3-吲哚甲醛(18),2-呋喃甲酸(19),5-羟甲基糠醛(20),(22E,24R)-5α,8α-epidioxy-ergosta-6,22-dien-3β-ol(21),(22E,24R)-5α,8α-epidioxy-ergosta-6,9,22-trien-3β-ol(22),(+)-lariciresinol 9'-stearate(23),芒柄花素(24)和尿苷(25)。其中,化合物1a,2a,4a,4b为分离过程中产生新的人工产物,其他25个化合物均为首次从该植物中分离得到。

The ethyl acetate extract of the flower of Albizia julibrissin was isolated and purified by silica gel,Sephadex LH-20and MCI GEL CHP-20P column chromatography to yield 29 compounds.Their structures were elucidated as 8-hydroxy-2,6-dimethyl-2E,6Z-octadienoic acid（1）,8-O-formyl-2,6-dimethyl-2E,6Z-octadienoic acid（1a）,8-hydroxy-2,6-dimethyl-2E,6E-octadienoic acid（2）,8-O-formyl-2,6-dimethyl-2E,6E-octadienoic acid（2a）,（2E,6S）-2,6-dimethyl-6-O-β-D-xylpyranosyloxy-2,7-menthiafolic acid（3）,clovan-2β,9α-diol（4）,2β-O-formyl-clovan-9α-ol（4a）,2β,9α-O-diformyl-clovan（4b）,vomifoliol（5）,（6S,9R）-roseoside（6）,vanillin（7）,4-O-ethylgallic acid（8）,3-ethoxy-4-hydroxy-benzoic acid（9）,p-hydroxybenzaldehyde（10）,gallic acid（11）,protocatechoic acid（12）,stearic acid（13）,palmitic acid（14）,2,3-dihydroxypropyl hexadecanoate（15）,linoleic acid（16）,scopoletin（17）,indole-3-carboxaldehyde（18）,2-furoic acid（ 19）,5-（ hydroxymethyl）-2-furaldehyde（ 20）,（22E,24R）-5α,8α-epidioxy-ergosta-6,22-dien-3β-ol（21）,（22E,24R）-5α,8α-epidioxy-ergosta-6,9,22-trien-3β-ol（22）,（ ＋）-lariciresinol 9＇-stearate（23）,formononetin（24） and uridine（25）.Compounds 1a,2a,4a and 4b were new artifacts from the separation process,and others were obtained from A.julibrissin for the first time.