肌酸激酶参与血压调节的新进展

Recent Progress of Creatine Kinase in Regulation of Blood Pressure

磷酸肌酸是参与细胞能量代谢的重要物质之一,肌酸激酶是组织细胞能量代谢主要的调节酶,主要存在于高耗能组织,如骨骼肌、心肌、脑等。已经证实肌酸激酶活性与血压独立相关,欧洲高血压学会2013年提出肌酸激酶抑制成为高血压治疗新靶点。β-胍基丙酸是一种与肌酸具有相似化学结构的蛋白质,可以通过竞争性抑制组织细胞摄取肌酸来减少肌酸激酶催化的能量流动。现主要介绍肌酸激酶与血压之间的关系以及β-胍基丙酸干预肌酸激酶对血压及心血管系统的影响。

Phosphocreatine is one of the main substances for cellular energy metabolism. Creatine kinase （CK） is the central regulatory enzyme of cellular energy metabolism. The enzyme is mainly expressed in tissues with high energy demands, including skeletal muscle, heart and brain. It has been demonstrated that creatine kinase activity is associated with blood pressure. In 2013, European Society Of Hy- pertension firstly indicate that intervention CK will be the new target for hypertension＇s therapy. Beta-guanidinopropionic acid （β-GPA）, an amino acid with a similar molecular structure like creatine, reduces the flux of the CK reaction by competitive inhibition of cellular creatine uptake. In this article,we systematically review the connection with CK and blood pressure and review the effect of cardiovascular system and blood pressure after β-GPA intervention.