心肌细胞和非心肌细胞在心力衰竭发展中的作用

Interactions of Cardiomyocyte and Non-myocytes in Development of Heart Failure

心脏包含各种类型的细胞,包括心肌细胞、心肌成纤维细胞、各种免疫细胞和血管细胞。最初的研究主要集中于心肌细胞,因为它直接反映了心脏的收缩功能。最近研究发现,心肌成纤维细胞的主要作用是维护心脏功能,参与心脏生理性和病理性重构。这些发现促使人们从研究心肌细胞转向了非心肌细胞,以及他们之间的相互作用。现将对心肌细胞与非心肌细胞间,主要是与心肌成纤维细胞,在心脏重塑和心力衰竭发展中的相互作用做一综述。

The heart contains various types of cells, including cardiomyocytes, cardiac fibroblasts, many kinds of immune cells and vascular cells. Initial studies mainly focused on cardiomyocytes, which directly reflect the contractile function of the heart. Recently, pivotal functions of cardiac fibroblasts have been revealed in the maintenance of cardiac function, physiological cardiac remodeling and pathological cardiac remodeling. These observations prompted a shift in the heart-related studies to include the complex communications between cardio- myocytes and other kinds of cardiac cells. This review will summarize the current knowledge regarding cell-cell interactions during cardiac re- modeling and the development of heart failure. We will especially focus on the interactions between eardiomyocytes and cardiac fibroblasts.