孟鲁司特钠辅助治疗婴幼儿毛细支气管炎疗效观察

Clinical Observation of Montelukast in the Treatment on Infants with Bronchiolitis

目的:观察孟鲁司特钠辅助治疗婴幼儿呼吸道合胞病毒毛细支气管炎的疗效及对临床症状、预后的影响。方法:将120例婴幼儿呼吸道合胞病毒毛细支气管炎患儿随机分为观察组62例和对照组58例,均采用相同的综合治疗方法,包括呼吸道管理、抗病毒(利巴韦林或重组人干扰素α-1b)、适量补液、吸氧,糖皮质激素(布地奈德混悬液)、β2受体激动剂(沙丁胺醇溶液)及抗胆碱能药(异丙托溴铵)雾化吸入,止咳、化痰、吸痰等治疗。观察组辅以睡前口服孟鲁司特钠每次4 mg,每日1次,疗程1个月。观察两组临床症状改善情况及疗效,随访6个月观察喘息复发情况。结果:观察组咳嗽、喘息等临床症状消失时间均短于对照组(P<0.05),喘息复发例数少于对照组(P<0.05);观察组总有效率95.2%,对照组82.8%,两组比较差异有统计学意义(P<0.05)。结论:孟鲁司特钠辅助治疗婴幼儿呼吸道合胞病毒毛细支气管炎,能明显改善患儿咳嗽、喘息等临床症状,提高临床疗效,减少或预防喘息复发和哮喘。

Objective： To observe the clinical effect, symptoms and prognosis of Montehkast for the respiratory syneytial virus bronchiolitis in infants. Methods： One hundred and twenty cases of respiratory syneytial virus bronchiolitis infants were randomly divided into an observation group （62 cases） and a control group （58 cases）. Both groups were given the same comprehensive treatment. The observation group was given montelukast 4 mg, one time per day, with a treatment course of one month. To observe the disappeared time of cough, wheezing, and crackles. After follow-up for six months, the number and frequency with wheezing recurrence in both groups were observed. Results： Compared with the control group, the disappeared time of cough, wheezing, and crackles in the observe group were all shorter significantly （P〈0.05）. The eases with wheezing recurrence decreased in the observe group compared with those in the control group （P〈0.05）. Conclusions： Montelukast is effective in relieving symptoms, reducing the recurrence of bronchiolitis and avoiding the occurrence of asthma.