芦荟胶外涂预防非小细胞肺癌靶向治疗相关性皮肤反应

The efficacy of external application of aloe vera gel against skin toxicity due to targeted therapy for non-small cell lung cancer

目的探讨芦荟胶外涂预防非小细胞肺癌分子靶向治疗相关性皮肤反应的效果。方法将59例入组患者按随机数字表法分为对照组(29例)与干预组(30例)。对照组采用常规护理措施,干预组在常规护理的基础上外涂芦荟胶预防皮肤不良反应。结果两组皮损程度、指甲/甲周改变程度比较,差异有统计学意义(均P<0.05);干预组首发皮损时间为(18.60±5.06)d,对照组为(12.20±4.47)d,两组比较,差异有统计学意义(P<0.01)。干预组皮损病程为(9.10±3.21)周,对照组为(12.45±4.19)周,两组比较,差异有统计学意义(P<0.05)。结论与靶向治疗同步外涂芦荟胶能够减少非小细胞肺癌靶向治疗相关性皮肤反应发生率,减轻皮损及指甲/甲周改变程度,缩短皮肤反应的病程。

Objective To investigate the efficacy of external application of aloe vera gel against skin toxicity due to targeted therapy for non-small cell lung cancer. Methods Fifty-nine patients were randomized into an intervention group （n= 30） and a control group （n= 29）. The control group just received routine nursing, while the intervention group received not only routine nursing but also external application of aloe vera gel. Results There were significant differences in skin lesions and nail/peri-nail changes（P〈0.05 for both） between the two groups. The appearance of the initial skin lesion was 18.60± 5.06 days in the intervention group, which was significantly later than that in the control group （12.20±4.47 days,P〈0.01）. Besides, the course of skin lesions in the inter- vention group was 9.10±3.21 weeks, significantly shorter than that in the control group （12.45±4.19 weeks, P〈0.05）. Con- clusion External application of aloe vera gel is beneficial for alleviating adverse skin toxicity associated with targeted therapy for non-small cell lung cancer.