摘要
目的改进埃索美拉唑镁合成工艺。方法以2-巯基-5-甲氧基-1H-苯并咪唑和2-氯甲基-3,5-二甲基-4-甲氧基吡啶为起始原料,经缩合、不对称氧化、成镁盐制得埃索美拉唑镁。结果总收率67.8%。结论本工艺操作简便,产品纯度高,成本低,工艺适合工业化生产。
Obiective To improve the synthesis process of esomeprazole magnesium.Methods With 2-mercapto-5-methoxybenzimidazole and 2-（chloromethyl）-4-methoxy-3,5-dimethylpyridine as starting materials,esomeprazole magnesium was synthesized by condensation,asymmetric oxidation and reaction with magnesium sulfate.Results The overall yield of esomeprazole magnesium was 67.8 ％.Conclusion The improved synthesis process of esomeprazole magnesium can be simple,easily controlled,cost-saving and can provide the product with high purity,and suitable for the industrial production of esomeprazole magnesium.
出处
《食品与药品》
CAS
2014年第3期185-187,共3页
Food and Drug
关键词
埃索美拉唑镁
质子泵抑制剂
合成
esomeprazole magnesium
proton pump inhibitor
synthesis
