摘要
[目的]观察经皮胫神经电刺激(percutaneous tibial nerve stimulation,PTNS)治疗国人女性药物难治性膀胱过度活动症(overactive bladder,OAB)的疗效。[方法]将128例国人女性OAB患者随机分成两组,分别采用PTNS(每周1次)、口服M受体阻滞剂(酒石酸托特罗定2mg,2次/d),共持续3个月,观察治疗前后OAB症状评分、日排尿次数、日尿失禁次数等指标并对M受体药物治疗组疗效不满意的25例患者行PTNS治疗。[结果]M受体组、PTNS组治疗前后组内患者在OAB症状评分、日排尿次数和日尿失禁次数上均有显著性改善(P<0.05),但在M受体组和PTNS组间OAB症状评分、日排尿次数和日尿失禁次数在治疗改善上均无显著性差异(P>0.05)。25例药物难治性OAB患者OAB症状评分由PTNS治疗前的(25.4±4.9)下降到治疗结束后的(17.2±3.1),前后差异有统计学意义(P<0.05)。[结论]PTNS治疗可显著改善国人女性OAB患者的排尿功能障碍,对于药物治疗无效或者疗效不满意的患者再行PTNS治疗也是可行有效的。
[Objective] To analyze the clinical efficacy of posterior tibial nerve stimulation(PTNS) for Chinese female patients with overactive bladder . [Methods] 128 overactive bladder(OAB) Chinese female patients were randomly divided into two groups. The PTNS group :patients were received posterior tibial nerve stimulation therapy once a week for 12 weeks(n=63).The M receptor blockers group:patients were received M receptor blockers(Tolterodine Tartrate Tablets 2mg, 2 times per day ) for 12weeks(n=65).And 25 patients who failed in M receptor blockers group received posterior tibial nerve stimulation therapy once a week for 12 weeks. Al the patients underwent a physiotherapeutic evaluation that included the overactive bladder questionnaire(OAB-q), micturition number per day and urinary incontinence number per day before and after treatment. [Result] The overactive bladder questionnaire(OAB-q) score, micturition number per day and urinary incontinence number per day declined significantly before and after treatment in each group. There were no significant differences in OAB-q score between PTNS group and M receptor blockers group. After the subsequent posterior tibial nerve stimulation, the overactive bladder questionnaire(OAB-q) score, micturition number per day and urinary incontinence number per day declined significantly in the 25 patients group who failed in M receptor blockers group. [Conclusion] Posterior tibial nerve stimulation(PTNS) provides good therapeutic effect for female primary overactive bladder and improves quality of life of patients. And the posterior tibial nerve stimulation therapy wil be a viable option in the drug-resistant overactive bladder(OAB) Chinese female patients.
出处
《浙江中医药大学学报》
CAS
2014年第4期411-413,418,共4页
Journal of Zhejiang Chinese Medical University
基金
浙江省卫生厅省医药卫生一般研究计划(2011kya151)~~