脑梗塞患者血同型半胱氨酸水平的分析

The analysis of serum homocysteine's level in patients with cerebral infarction

目的探讨脑梗塞患者血同型半胱氨酸水平及其相关因素分析。方法选择广东医学院附属医院2011年06月至2012年05月脑梗死患者205例及选择同期在本院体检的健康体检者,共228例。分别为脑梗塞组和正常对照组,检测收集两组血清同型半胱氨酸水平,同时收集脑梗塞组患者肝功能、肾功能、血糖相应指标。结果脑梗塞组血同型半胱氨酸水平与正常对照组比较,差异有统计学意义(P<0.05);脑梗塞患者血同型半胱氨酸水平与高血糖或肝、肾功能损伤有相关性。ALT、GGT、性别是脑梗塞患者血同型半胱氨酸的影响因素。结论高同型半胱氨酸血症是脑梗塞发病的独立相关危险因素,血糖或肝、肾功能异常及性别可影响患者血同型半胱氨酸水平。对心脑血管疾病高危人群定期进行血同型半胱氨酸水平的检测对心脑血管疾病的发生和预报有重要的临床价值。

Objective To investigate the relationship between homocysteine and cerebral infarction.Methods Select 205 patients with cerebral infarction from Guangdong Medical College Hospital from January 2011 to May 2012 and the same period of healthy persons from hospital examination,a total of 228 cases,for cerebral infarction group and the nor-mal control group,the detection of the collection of homocysteine levels,while collecting the corresponding index of liver function,kidney function,Glu with cerebral infarction group patients.Results Infarction group homocysteine levels compared with normal control group,the difference was statistically significant （P 〈0.05）.The serum homocysteine’s level in patients with cerebral infarction is associated to high blood sugar or liver,renal injury.ALT,GGT,gender is the impact factors of cerebral infarction in patients with homocysteine.Conclusion High with hyperhomocysteinemia is an independent risk factor for cerebral infarction,blood sugar or liver,renal dysfunction,and sex can affect the homocys-teine levels of patients.At high risk of cardiovascular disease for the detection of homocysteine levels on a regular basis on the occurrence and prediction of cardiovascular and cerebrovascular diseases has important clinical value.