化痰通络中药对痰瘀互结型高血压病患者血压及血管内皮生长因子的影响

Influence of Chinese Medicine of Resolving Phlegm and Dredging Collaterals in Treating Hypertension Patients with Accumulation of Phlegm and Blood Stasis

目的观察化痰通络中药治疗痰瘀互结型高血压病的临床疗效及其对血管内皮生长因子(VEGF)的影响。方法将68例痰瘀互结型高血压患者随机分为2组,对照组(34例)给予硝苯地平控释片,治疗组(34例)在对照组治疗基础上加用化痰通络中药,疗程均为12周。观察2组的降压疗效,并比较2组治疗前后血压、中医证候积分、血清VEGF水平。结果对照组、治疗组降压总有效率分别为79.4%(27/34)、91.2%(31/34),2组比较差异有统计学意义(P<0.05)。2组治疗后收缩压、舒张压、中医证候积分、血清VEGF水平均较治疗前明显下降(P<0.01),治疗组各项指标均优于对照组(P<0.05),且不良反应发生例数少。结论化痰通络中药配合降压药治疗痰瘀互结型高血压病的降压疗效显著,可改善患者临床症状,降低血清VEGF水平,在一定程度上改善血管内皮功能。

Objective To observe the clinical efficacy of Chinese medicine of resolving phlegm and dredging collaterals in treating hypertension, and its effect on vascular endothelial growth factor （VEGF）. Methods Sixty-eight hypertension patients with accumulation of phlegm and blood stasis were randomly divided into two groups, 34 cases of control group received Nifedipine controlled-release tablets, 34 cases of treatment group received Chinese medicine of resolving phlegm and dredging collaterals additionally, with treatment course of 12 weeks. Antihypertensive efficacy of the two groups was observed, and blood pressure, TCM symptom score and serum VEGF level of two groups before and after treatment were compared. Results The total effective rate of the control group and the treatment group was 79.4%（27/34） and 91.2%（31/34） respectively, the difference between them was significant （P〈0.05）. After treatment, SBP, DBP, TCM syndrome score and serum VEGF level of the two groups were significantly decreased （P〈0.01）. The indexes of the treatment group was better than the control group （P〈0.05）, and the cases with adverse reaction of the treatment group was less than the control group. Conclusion Chinese medicine of resolving phlegm and dredging collaterals has significant antihypertensive effect in treating hypertension with accumulation of phlegm and blood stasis, can improve patients’ clinical symptoms, reduce serum VEGF level, thus improve vascular endothelial function to some extent.