九味镇心颗粒联合经颅磁刺激治疗广泛性焦虑的临床观察

Clinical Observation on JiuWer Zhenxin Particles Combined with Transcranial Magnetic Stimulation in the Treatment of Generalized Anxiety Disorder

目的探讨九味镇心颗粒联合经颅磁刺激对广泛性焦虑(GAD)的治疗作用及安全性。方法 68例GAD患者随机分为两组,对照组33例,口服九味镇心颗粒,治疗组35例,在口服九味镇心颗粒的同时,加用经颅磁刺激治疗。疗程4周,两组基础治疗相同,均进行心理护理、疏导及支持治疗。以汉密尔顿焦虑量表(HAMA)对患者的焦虑程度及改善状况进行评定,并将两组疗效和安全性作对比。结果 HAMD评分两组治疗前后对比,差异均有统计学意义(P<0.05),治疗后两组间比较差异有统计学意义(P<0.05);总有效率治疗组88.57%,对照组78.79%,两组比较差异有统计学意义(P<0.05);不良反应发生率两组比较无统计学意义。结论九味镇心颗粒联合经颅磁刺激治疗GAD安全有效。

Objective To probe into the effect Jiuuer Zhenxin（JZP）particles combined with transcranial magnetic stimulation ea-sing on generalized anxiety.Methods Sixty eight patients were randomly divided into two groups：Control group（n=33）treated with Jiu Wer Zhen xin particles JZP and observation group（n=35）treated with（JZP）combined with transcranial magnetic stimula-tion.Hamilton anxiety scale and the side effects scale of the two groups were recorded and compared pre and post treatment.Re-sults Compared with the pre treatment,there were significant differences in Hamilton anxiety marks in both groups after treat-ment.There was significant differences in overall response rate between two groups,and no significant differences in side effects be-tween two groups.Conclusion JZP combined with transcranial magnetic stimulation was effective in the treatment of generalized anx-iety disorder with better effect and slight side effect.