CEA、CK19-2G2与EB-VCA-Ig联合检测对鼻咽癌的诊断价值

The diagnostic value of CEA,CK19-2G2 and EB-VCA-Ig combined detection for nasopharyngeal carcinoma

目的研究癌胚抗原(CEA)、角蛋白(CK)19-2G2与EB病毒衣壳抗原IgA(EB-VCA-Ig)联合检测对鼻咽癌的临床诊断价值。方法对82例鼻咽癌患者(恶性组),65例良性鼻咽疾病患者(良性组)及58例健康体检者(对照组)血清CEA、CK19-2G2及EB-VCA-Ig进行检测。CEA、CK19-2G2的检测采用化学发光法,EB-VCA-Ig检测采用酶联免疫吸附测定(ELISA)法。结果恶性组患者血清CK19-2G2及EB-VCA-Ig浓度均高于良性组及对照组(P<0.05)。单项CK19-2G2检测鼻咽癌的敏感性为48.78%,特异性为83.74%;CEA联合EB-VCA-Ig检测鼻咽癌的敏感性为53.44%,特异性为86.99%;3项指标联合检测鼻咽癌的敏感性为71.95%,特异性为80.49%。3项指标联合检测可显著提高早期及进展期患者的阳性检出率。结论 CEA、CK19-2G2及EB-VCA-Ig联合检测对鼻咽癌的诊断具有重要价值。

Objective To study the clinical diagnostic value of carcinoembryonic antigen （CEA） ,cytokeratin（CK）19-2G2 and EB virus capsid antigen Ig （EB-VCA-Ig） combined detection for nasopharyngeal carcinoma .Methods Serum CEA ,CK19-2G2 and EB-VCA-Ig of 82 patients with nasopharyngeal carcinoma （malignant group） ,65 patients with benign nasopharyngeal diseases （benign group） and 58 healthy people（control group） were detected .Chemiluminescence was employed to detect CEA and CK19-2G2 ,and enzyme-linked immunosorbent assay（ELISA） was used to assay EB-VCA-Ig .Results Serum CK19-2G2 and EB-VCA-Ig concen-trations of patients in malignant group were higher than those in the benign group and control group ,respectively （P〈0 .05） .The sensitivity and specificity of individual CK 19-2G2 detection for nasopharyngeal carcinoma were 48 .78% ,and 83 .74% ,respectively , those of CEA and EB-VCA-Ig combined detection were 53 .44% and 86 .99% ,respectively ,and those of three indicators combined detection were 71 .95% and 80 .49% ,respectively .Three indicators combined detection significantly increased the positive detection rates in patients with early and advanced stages .Conclusion CEA ,CK19-2G2 and EB-VCA-Ig combined detection possesses impor-tant value for nasopharyngeal carcinoma diagnosis .