医院人群的血清乙型肝炎病毒标志物分布特征的分析

Analysis of distribution characteristics of serum hepatitis B virus markers of population in hospital

目的探讨医院人群血清乙型肝炎病毒（HBV）血清学标志物的分布特征,为乙型肝炎预防与控制提供依据。方法收集接受HBV血清学检测的医院人员11 210例,将其按年龄分为：〉0~25岁组（n=3 553）、〉25~50岁组（n=7 651）。采用酶联免疫吸附测定（ELISA）及Roche Cobas E601型全自动电化学发光免疫分析仪检测血清HBV表面抗原（HBsAg）、抗HBV表面抗体（HBsAb）、HBV e抗原（HBeAg）、抗HBV e抗体（HBeAb）及抗HBV核心抗体（HBcAb）。结果 〉0~25岁组、〉25~50岁组受检者HBsAg阳性率分别为16.16%、21.19%。总体HBsAg、HBsAb阳性率及全阴性率为19.59%（2 195/11 204）、37.02%（4 148/11 204）及11.84%（1 327/11 204）。结论医院人群血清HBV标志物分布特征可为采取有效的乙型肝炎防控措施提供了可靠依据。

Objective To investigate the distribution characteristics of serum hepatitis B virus （HBV） markers of population in hospital and to provide the basis for prevention and control of virus B hepatitis .Methods 11 210 people in hospital who had accepted HBV serological testing were enrolled ,and were divided into 〉0 -25-year old group（n=3 553） and 〉25 -50-year old group（n=7 651） according to their ages .Enzyme-linked Immunosorbent Assay（ELISA） and Roche Cobas E601 Automatic Electro-chemiluminescence immunoassay analyzer were employed to detect serum HBV surface antigen （HBsAg ） ,anti-HBV surface anti-body（HBsAb） ,HBV e antigen（HBeAg） ,anti-HBV e antibody（HBeAb） and anti-HBV core antibody（HBcAb） .Results HBsAg positive rates of subjects in 〉 0 -25-year old group and 〉 25 -50-year old group were 16 .16% and 21 .19% ,respectively .The overall positive rates of HBsAg and HBsAb and full-negative rate were 19 .59% （2 195/11 204） ,37 .02% （4 148/11 204） and 11 .84% （1 327/11 204） ,respectively .Conclusion Distribution characteristics of HBV markers of population in hospital may pro-vide a reliable basis for taking effective protective and control measures against virus B hepatitis .