妊娠期糖尿病患者肾损害与血清Cys C水平的相关性研究

A research of correlation between renal damage of patients with gestational diabetes mellitus and level of serum cystatin C

目的探讨妊娠期糖尿病（GDM）患者肾损害与血清胱抑素C（Cys C）的相关性。方法回顾性分析2011年1月至2012年12月于该中心顺产单胎的产妇,选择经口服葡萄糖耐量试验（OGTT）检测确诊为GDM的400例产妇,将孕30~40周检测的24h尿蛋白量大于0.15g的200例产妇作为GDM组,而将24h尿蛋白量不高于0.15g的200例产妇作为GDM对照组。将排除GDM的200例健康产妇作为正常组。于孕30~40周检测血清尿酸、肌酐、尿素、Cys C,并检测24h尿蛋白量。结果GDM组患者血清尿酸、Cys C水平高于GDM对照组（P〈0.05）,而2组血清尿素、肌酐的差异无统计学意义（P〉0.05）;24h尿蛋白量与血清尿酸、Cys C呈正相关（r分别为0.715、0.863,P〈0.05）,与尿素、肌酐无明显相关（P〉0.05）。结论血清Cys C可作为GDM患者肾损害的早期诊断及监测指标。

Objective To explore the correlation between renal damage of patients with gestational diabetes mellitus （GDM ） and level of serum cystatin C（Cys C） .Methods Eutocia puerperas with single birth in this center from January 2011 to December 2012 were retrospectively analyzed .400 puerperas ,who were confirmed as GDM by oral glucose tolerance test （OGTT） detection ,were collected .Among them ,200 puerperas with 24 h urinary protein content more than 0 .15 g during their 30 to 40 weeks of pregnancy were served as GDM group ,while another 200 puerperas with those not more than 0 .15 g as GDM control group .200 healthy puer-peras without GDM were served as the normal group .Serum uric acid ,creatinine ,urea ,Cys C and 24 h urinary protein content of them during their 30 to 40 weeks of pregnancy were detected .Results Serum uric acid and Cys C of patients in GDM group were obviously higher than those in the GDM control group（P〈0 .05） ,while the differences of serum urea ,creatinine between the two groups showed no statistical significance （P〉0 .05） .24 h urinary protein content was positively correlated with the serum uric acid and Cys C（r=0 .715 ,0 .863 ,P〈0 .05） ,and had no correlation with urea and creatinine （P〉0 .05） .Conclusion Serum Cys C may be used as indicators for early diagnosis and monitoring of renal damage in patients with GDM .