不同剂型利福平在治疗肺结核中的疗效对比

The Observation and Comparison of the Clinical Effectiveness of Pulmonary Tuberculosis Curing by Rifampicin Caps and Rifampicin Injection

目的:比较利福平胶囊和利福平注射液治疗肺结核的临床疗效。方法:120例肺结核患者分为观察组和对照组,每组60例,两组患者均采用2HRZE/4HR标准化疗方案治疗,观察组给予利福平注射液治疗,对照组给予利福平胶囊治疗。结果:疗程结束时观察组和对照组痰菌阴转率分别为91.7%、78.3%;病灶吸收率分别为86.7%、61.7%,两组比较差异均有统计学意义(P<0.05)。两组空洞闭合、缩小例数及不良反应发生率比较差异均无统计学意义(P>0.05)。结论:利福平注射液治疗肺结核疗效显著,副作用小,有较好的临床应用价值。

Objective：To observed and compared the clinical effectiveness of pulmonary tuberculosis curing by rifampicin caps and rifampicin injection. Method：One hundred and twenty cases of pulmonary tuberculosis patients were divided into the observation group（n=60） and the control group（n=60）,all the cases were treated with 2HREZ/4HR standard chemotherapy formula. The observation group were treated by Rifampicin Injection during the intensify phase,while the control group were treated by taking Rifampicin Capsules. Result：The sputum negative conversion rates were 91.7%and 78.3%in the observation group and the control group respectively,and the lesions absorption rates of two groups were 86.7%and 61.7%respectively,and the difference between the two groups were all statistically significant（P〈0.05）. It had no significant difference between two groups with the hole closed and narrow cases,incidence of adverse reactions. Conclusion：Rifampicin injection has a good curative effect in treating pulmonary tuberculosis,which fewer adverse reactions. It is of great value in the clinical practice.