肝主疏泄调节易激惹诱导大鼠NPY与快速性心律失常相关性研究

Correlation Between TCM Liver Controlling Dispersion Theory and Rapid Arrhythmia and Its Mechanism

目的:探讨中医"肝主疏泄"理论与快速性心律失常的相关性及发生机制。方法:选40只SD大鼠,采用激惹刺激,诱导大鼠出现心律失常,动态检测观察造模前后大鼠血浆神经肽Y(NPY)变化,并同时记录相应各个时段心电图的变化。利用ELISA方法检测大鼠血清中NPY的变化。结果:大鼠经情志刺激诱导成为心律失常模型前后血浆NPY有明显升高(与造模前比较,P<0.01),而且这种状态持续存在。大鼠经情志刺激诱导后,ECG表现为以快速性心律失常为特征的心电表现。结论:肝主疏泄调节易激惹与快速性心律失常的成正相关。NPY升高在快速性心律失常病理的变化中起着重要作用。

Objective：To investigate the correlation between TCM liver controlling dispersion theory and the rapid arrhythmia and its mechanism. Methods ：40 SD rats, by the bowel stimulation, were induced arrhythmia. Before and after modeling, the plasma neuropeptide Y （NPY）changes and the corresponding changes in each period of ECG were recorded. Changes in serum NPY was detected by using ELISA method. Results：The plasma NPY was increased significantly （P 〈 0. 01 ）, and this state persisted. ECG was characterized with tachyarrhythmia. Conclusion ： Liver controlling dispersion theroy regulating bowel is associated with rapid arrhythmia. The elevation of NPY plays an important role in the pathological changes of tachyarrhythmia